科研方向 – 分子药理及抗炎免疫

作者:2021/04/21 03:10浏览次数:27


主要成员:

黄学应、庞刚、张晓明

 

研究领域:

该方向主要致力于关节炎、病理性瘢痕等疾病治疗的分子药理学,心血管药理学和抗炎免疫药理学等方面的研究。

 

科研课题:

重组人内抑素促进兔耳增生性瘢痕成纤维细胞转归作用的机制研究(黄学应,国自然)

索拉非尼(sorafenib)促进大鼠佐剂性关节炎转归作用及机制研究(黄学应,省教育厅)

内侧前额叶5-羟色胺5-HT2A受体对小鼠海洛因依赖和复发行为的调控及机制研究(庞刚,省自然)

血管生成抑制剂抑制病理性瘢痕增生的作用机制研究(张晓明,省教育厅)

 

代表性成果:

Wang ZZ, Huang TY, Gong YF, Zhang XM, Feng W, Huang XY. Effects of sorafenib on fibroblast-like synoviocyte apoptosis in rats with adjuvant arthritis. Int Immunopharmacol. 2020;83:106418.

Zhang K, Wang F, Huang J, Lou Y, Xie J, Li H, Cao D, Huang X. Insulin-like growth factor 2 promotes the adipogenesis of hemangioma-derived stem cells. Exp Ther Med. 2019;17(3):1663-1669.

Wang F, Li H, Lou Y, Xie J, Cao D, Huang X. Insulinlike growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas. Mol Med Rep. 2019;19(4):2825-2830.

Wang ZZ, Liu F, Gong YF, Huang TY, Zhang XM, Huang XY. Antiarthritic Effects of Sorafenib in Rats with Adjuvant-Induced Arthritis. Anat Rec (Hoboken). 2018;301(9):1519-1526.

Gong YF, Zhang XM, Yu J, Huang TY, Wang ZZ, Liu F, Huang XY. Effect of recombinant human endostatin on hypertrophic scar fibroblast apoptosis in a rabbit ear model. Biomed Pharmacother. 2017;91:680-686.

Gong YF, Zhang XM, Liu F, Wang ZZ, Deng XF, Jiao Y, Li XJ, Huang XY. Inhibitory effect of recombinant human endostatin on the proliferation of hypertrophic scar fibroblasts in a rabbit ear model. Eur J Pharmacol. 2016;791:647-654.

Pang G, Wu X, Tao X, Mao R, Liu X, Zhang YM, Li G, Stackman RW, Jr., Dong L, Zhang G. Blockade of Serotonin 5-HT2A Receptors Suppresses Behavioral Sensitization and Naloxone-Precipitated Withdrawal Symptoms in Morphine-Treated Mice. Front Pharmacol. 2016;7:514.


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