科研方向 – 神经损伤及修复

作者:2021/04/21 02:36浏览次数:57



主要成员:

任振华、孔艳

 

研究领域:

该方向主要致力于间充质干细胞、神经干细胞以及抑郁症发病机制等方面的研究。

 

科研课题:

突触发生期酒精介导CaMKII/GSK3β信号失衡促进脊髓背角GABA能神经元凋亡(任振华,国自然)

MCPIP1在急性酒精性胰腺损伤中的作用研究(任振华,省教育厅)

胶质母细胞瘤干性起源的分子生物学研究(任振华,国自然)

雌激素干预胰岛β细胞再生的机制研究(任振华,省自然)

 

代表性成果:

Wang J, Zhang Y, Liu Z, Yang Y, Zhong Y, Ning X, Zhang Y, Zhao T, Xia L, Geng F, Tao R, Fan M, Ren Z, Liu H. Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms. BMC Psychiatry. 2020;20(1):410.

Liu Z, Zhang Y, Zhao T, Wang J, Xia L, Zhong Y, Yang Y, Ning X, Zhang Y, Ren Z, Liu H. A higher body mass index in Chinese inpatients with chronic schizophrenia is associated with elevated plasma orexin-A levels and fewer negative symptoms. Nord J Psychiatry. 2020;74(7):525-532.

Ren Z, Wang X, Xu M, Frank JA, Luo J. Minocycline attenuates ethanol-induced cell death and microglial activation in the developing spinal cord. Alcohol. 2018;79:25-35.

Ren Z, Wang X, Yang F, Xu M, Frank JA, Wang H, Wang S, Ke ZJ, Luo J. Ethanol-induced damage to the developing spinal cord: The involvement of CCR2 signaling. Biochim Biophys Acta Mol Basis Dis. 2017;1863(11):2746-2761.

Ren Z, Yang F, Wang X, Wang Y, Xu M, Frank JA, Ke ZJ, Zhang Z, Shi X, Luo J. Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation. Toxicol Appl Pharmacol. 2016;308:11-19.

Ren Z, Wang X, Xu M, Yang F, Frank JA, Ke ZJ, Luo J. Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas. Oncotarget. 2016;7(34):54303-54316.


Copyright © 版权所有. All Rights Reserved

地址:安徽省合肥市蜀山区梅山路81号电话:0551-65161146、65161147邮编:230032