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张诗武
2012-11-25

 

 

姓名

 张诗武

性别

 男

出生年月

 1972-11

导师资格

 2010

职称

  教授

职务

 

最高学历

 博士

毕业时间

 2008-07

最高学位

  博士

授予时间

 2008-07

联系方式

办公电话:

E-mail:zhangshiwu666@yahoo.com.cn

教育背景

 1992-1997  武警医学院(天津医科大学委培),临床医学本科

2000-2003  天津医科大学,病理学与病理生理学,硕士研究生(统招)

2005-2008   天津医科大学,肿瘤学博士(统招)

2010-至今   美国M.D.Anderson癌症中心 博士后

工作经历

1997-2003   武警医学院 病理学助教

2003-2004   武警医学院 讲师

2004-2007   天津医科大学附属肿瘤医院 讲师

2007-2009   天津医科大学附属肿瘤医院 副教授

2009-至今   安徽医科大学病理学教研室 副教授

2012-至今   安徽医科大学校聘 教授

主持或参加科研项目(2007-2012

1.国家自然科学基金《外源性雌孕激素诱导TA2雌鼠乳腺癌发生相关分子机制》(编号:81071631),2011-201332万元,项目负责人

2.安徽省教育厅重点项目《TA2小鼠妊娠相关乳腺癌发病相关机制》(编号:KJ2010A179,2009年,5万元,项目负责人

3.安徽省高层次创新创业资金资助项目《妊娠对TA2小鼠自发性乳腺癌发生、发展影响的初步研究》。(编号:2009Z033),2010-20126万元,项目负责人

4. 国家自然科学基金重点项目《肿瘤血管生成新模式——血管生成拟态的形成机制及意义》(编号:30830049,在研)2008年,160万元,第二完成人

5. 国家自然科学基金面上项目《线形程序性坏死在黑色素瘤血管生成拟态形成过程中作用及相关机制》(编号:307708282007年,29万元,第二完成人;

6. 天津医科大学博士学位论文课题创新研究基金《程序性坏死和微环境在黑色素瘤VM形成过程中的作用》(编号:yjs200605),2006-2008年,4万元,项目负责人;

发表论文(2007-2012

通讯作者、第一作者或共同第一作者SCI收录论文2007-2012

1. Jia L, Zhang S, Ye Y, Li X, Mercado-Uribe I, Bast RC Jr, Liu J. Paclitaxel Inhibits Ovarian Tumor Growth by Inducing Epithelial, Cancer Lett.2012 Aug 15. [Epub ahead of print] (co-first author) (IF: 4.238)

2. Yin Y, Yang Z, Zhang S. Combined treatment with exogenous estradiol and progesterone increases the incidence of breast cancer in TA2 mice without ovaries. Cancer Lett. 2011; 311(2): 171-176. (corresponding author) (IF: 4.238)

3. Gu Y, Zhang S, Wu Q, Xu S, CuiY, Yang Z, Zhao X, Sun B. Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer. J Exp Clin Canc Res. 2010; 29: 6. (co-first author) (IF: 2.148)

4.            Zhang S, Li M, Zhang D, Xu S, Wang X, Liu Z, Zhao X, Sun B. Hypoxia influences linearly patterned programmed cell necrosis and tumor blood supply patterns formation in Melanoma. Lab Invest. 2009; 89(5): 575-586. (IF: 4.602)

5.      5.Chen L, Sun B, Zhang S, Zhao X, He Y, Zhao S, Lin T, Li X. Influence of microenvironments on microcirculation patterns and tumor invasion-related protein expression in melanoma. Oncol Rep. 2009; 21(4): 917-923. (co-first author) (IF: 1.588)

6. Chen L, Zhang S, Li X, Sun B, Zhao X, Zhang D, Zhao S. A pilot study of vasculogenic mimicry immunohitochemical expression in intraocular melanoma model. Oncol Rep. 2009;21(4):989-994. (co-first author) (IF: 1.588)

7.      7.Sun B, Zhang S, Zhang D, Li Y, Zhao X, Luo Y, Guo Y. Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer. Clin Cancer Res. 2008; 14(21): 7050-7059. (co-first author) (IF: 7.742)

8.        Zhang S, Qi L, Li M, Zhang D, Xu S, Wang N, Sun B. Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer. J Exp Clin Canc Res. 2008; 27(1): 62. (IF: 2.148)

9.      9.Zhang S, Li M, Gu Y, Liu Z, Xu S, Cui Y, Sun B. Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J Exp Clin Canc Res. 2008; 27(1): 60. (IF: 2.148)

10.        Zhang S, Zhang D, Sun B. Vasculogenic Mimicry: Current Status and Future Prospects. Cancer Lett. 2007; 254(2): 157-164. (IF : 4.423)

11.    Sun B, Zhang D, Zhang S, Zhang W, Guo H, Zhao X. Hypoxia Influences  Vasculogenic Mimicry Channel Formation and Tumor Invasion-related Protein Expression in Melanoma. Cancer Lett. 2007; 249: 188-197. (co-first author) ( IF : 4.423)

12.    Sun B, Zhang S, Zhang D, Gu Y, Zhang W, Zhao X. The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model. J Cancer Res Clin. 2007; 133(12): 979-985. (co-first author) (IF: 2.558)

13.    Sun B, Zhang S, Zhang D, Liu Y, Li Y, Rong Z, Zhu Y, Jia X. Clusterin is associated with spontaneous breast cancer in TA2 mice. FEBS Lett. 2007; 581(17): 3277-3282. (co-first author) (IF: 3.538)

14.    Sun B, Zhang S, Zhang D, Yin X, Wang S, Gu Y, Wang Y. Doxycycline Influences Microcirculation Patterns in B16 Melanoma. Exp Biol Med. 2007; 232: 1300-1307. (co-first author) (IF: 2.526)

 

非第一作者SCI收录论文2007-2012:

1.Shan W, Mercado-Uribe I, Zhang J, Rosen D, Zhang S, Wei J, Liu J. Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. Cell Cycle. 2012;11(11):2107-2113.

2.Guo X, Liu G, Schauer IG, Yang G, Mercado-Uribe I, Yang F, Zhang S, He Y, Liu J. Overexpression of the β subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis. Am J Pathol. 2011;179(3):1385-1393.

3.Wang X, Huang C, Sun B, Gu Y, Cui Y, Zhao X, Li Y, Zhang S. The effect of high gravidity on the carcinogenesis of mammary gland in TA2 mice. Am J Reprod Immunol. 2010; 63(5): 396-409. (IF: 2.172)

4.Li M, Gu Y, Zhang Z, Zhang S, Zhang D, Saleem AF, Zhao X, Sun B. Vasculogenic mimicry: a new prognostic sign of gastric adenocarcinoma. Pathol Oncol Res. 2010; 16(2): 259-266. (IF: 1.152)

5.Sun T, Zhao N, Zhao X, Gu Q, Zhang S, Che N, Wang X, Du J, Liu Y, Sun B. Expression and functional significance of Twist 1 in hepatocellular carcinoma: Its role in vasculogenic mimicry. Hepatology. 2009; 51(2): 545-556. (IF: 10.84)

6. Chen L, Sun B, Zhang S, Zhao X, He Y, Zhao S, Lin T, Li X. Influence of microenvironments on microcirculation patterns and tumor invasion-related protein expression in melanoma. Oncol Rep. 2009; 21(4): 917-923. (IF: 1.588)

7. Sun Y, Sun B, Wang J, Cai W, Zhao X, Zhang S, Hao X. Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma. Cancer Sci. 2009; 100(6): 1018-1025. (IF: 3.771)

8.Sun B, Qie S, Zhang S, Sun T, Zhao X, Gao S, Ni C, Wang X, Liu Y, Zhang L. Role and mechanism of vasculogenic mimicry in gastrointestinal stromal tumors. Hum Pathol. 2008; 39(3): 444-451. (IF: 2.961)

9.Wang JY, Sun T, Zhao XL, Zhang S, Zhang DF, Gu Q, Wang XH, Zhao N, Qie S, Sun BC. Functional Significance of VEGF-a in Human Ovarian Carcinoma: Role in Vasculogenic Mimicry. Cancer Biol Ther. 2008; 7(5): 758-766. (IF: 2.711)

10.Zang F, Sun B, Zhao X, Niu R, Zhang S, Yu M, Wei X, Zhang L. Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29. Cell Biology  International 2008; 32(3): 329-336. (IF: 1.8)

11.Sun B, Sun Y, Wang J, Zhao X, Zhang S, Liu Y, Li X, Feng Y, Zhou H, Hao X. The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. Cancer Sci 2008; 99(7): 1355-1361. (IF: 3.771)

12.Zhang B, Cao X, Liu Y, Cao W, Zhang F, Zhang S, Li H, Ning L, Fu L, Niu Y,  

Niu R, Sun B, Hao X. Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer 2008; 8: 83. (IF: 2.736)

13Cao W, Zhang B, Liu Y, Li H, Zhang S, Fu L, Niu Y, Ning L, Cao X, Liu Z, Sun B. High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival. Am J Clin Pathol. 2007; 128(3): 430-436. (IF: 2.473)

其他自2007年来中文期刊发表论文二十余篇,详细情况略。

编写著作(2007-2012

1. 副主编:《纵隔肿瘤病理学》人民卫生出版社 20083月第一版

2.参编:吴秉铨,刘彦仿主编.免疫组织化学病理诊断.90万字. 北京科学技术出版社,200710月第一版。

3.参编:《Encyclopedia of Cancer(欧洲百科全书)》20083月出版,欧洲Springe出版公司。

获得的成果与奖励:

1.天津市科技进步一等奖《大肠癌发生与器官特异性转移机制及干预的研究》,2006年,第三完成人。

2.天津市自然科学三等奖《双向分化恶性肿瘤血管生成拟态及其分子机制的研究》,2005年,第三完成人。

3.高等学校科学研究优秀成果奖《乳腺癌发生和转移生物学特征基因群的研究》,2010年,第七完成人

指导的毕业和在读研究生情况:

作为二导,指导硕士毕业生12名,均已经毕业(天津医科大学)

作为二导,指导博士毕业生3名,均已经毕业(天津医科大学)

作为一导,指导硕士研究生1名,先在读(安徽医科大学)